KEGG   REACTION: R04676
Entry
R04676                      Reaction                               
Name
17alpha,20alpha-dihydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
17alpha,20alpha-Dihydroxycholesterol + 2 Oxygen + 4 H+ + 4 Reduced adrenal ferredoxin <=> 17alpha-Hydroxypregnenolone + 4-Methylpentanal + 3 H2O + 4 Oxidized adrenal ferredoxin
Equation
C05499 + 2 C00007 + 4 C00080 + 4 C00662 <=> C05138 + C02373 + 3 C00001 + 4 C00667
Comment
two-step reaction (similar to R04854+R03933)
Reaction class
RC01193  C05138_C05499
RC01543  C02373_C05499
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R04676  17alpha,20alpha-Dihydroxycholesterol + 2 Oxygen + 4 H+ + 4 Reduced adrenal ferredoxin <=> 17alpha-Hydroxypregnenolone + 4-Methylpentanal + 3 H2O + 4 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

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